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SYNVISC® 3x2ml

Manufacturer: Genzyme
Active Substance(s) : Hylan g-f 20
Strength: 8mg/ml
Pack Size: 3-2ml prefilled syringes
Accessories: Package insert
You can save $60.00 if you add an additional 5 units to your cart.

Synvisc Product Specifications

Synvisc is an animal-based orthopedic injectable designed to lubricate synovial joints crippled by the debilitating symptoms of arthritis disease. It contains 8mg/ml of chemically cross-linked hylan extracted from the fleshy crests on top of rooster heads, which are also known as rooster combs. The orthopedic injectable gel closely mimics the properties and actions of naturally-occurring synovial fluid in respect to maintaining joint health and mobility. The two varieties in this orthopedic range are Synvisc and Synvisc One. These two products share the same gel formulation but have different packaging volume. The former comes with three prefilled 2ml glass syringes for a total of 3 injections, while the latter comes with only 1 prefilled 6ml glass syringe for a single-use.

What is Synvisc formulated to do?

Under normal circumstances, the ends of bones encased within a synovial joint are sheathed by a layer of articular cartilage. The cartilage produces lubricating synovial fluid continuously for smooth movements. However, factors like genetics, excessive body weight, and normal wear-and-tear cause the cartilage to disintegrate, resulting in arthritis. Synvisc is then used as a viscosupplement to help lubricate synovial joints affected by debilitating arthritis. It contains animal-based hylan, which is also found in synovial fluid. Hylans are then chemically cross-linked to share the same viscoelastic properties as the naturally-occurring hylan in human synovial fluid. Hence, the orthopedic injections are well-tolerated by patients. This orthopedic gel can only be done through intraarticular injections into a knee joint without any effusion or skin inflammation surrounding it.


The Synvisc family of products are designed and manufactured by Sanofi Genzyme. Genzyme was initially an American biotechnology company but became a full subsidiary company of Sanofi in 2011.

The Synvisc family of products are manufactured in the USA.

What else do you need to know?

When can it cause side effects?

Since these orthopedic injectables are made using hylans derived from rooster combs, serious hypersensitive reactions, such as a swollen tongue and mouth; difficulty breathing, swallowing, and talking; hives, nausea; headaches; and muscle aches, can occur in patients who are allergic to avian products, like eggs, poultry, and feathers.

Which skin type is it good for?

Before the procedure, doctors should ensure that the areas to be injected are not infected or inflamed. Doctors must also remove any fluid buildup from the affected joints before injecting the arthritic knees with either of these viscosupplements.

What is it made without?

This viscosupplementation gel is purified to be free from pyrogens and contaminants. Hence, the risk of immunogenic and rejection reactions is minimized.

Information about packaging

Synvisc is supplied in 3 preloaded 2ml glass syringes.

Is it approved by FDA?

Yes, this viscosupplement is approved by the US Food and Drug Administration (FDA) to be used in the management of knee joints crippled by arthritis.

What are the differences between the products?

These 2 variations of knee injectables share the same active composition. The only difference lies in the packaging volume.

What is the suggested usage?

This viscosupplement is intended to alleviate pain, inflammation, and the lack of mobility in knee joints affected by arthritis. Patients who are unable to manage their condition via analgesics, oral supplements, mobility support gears, or other methods will benefit greatly from this treatment.

What is the composition?

This orthopedic injectable gel is composed of hylan A fluid and hylan B gel that is all reconstituted in a buffer solution with an appropriate pH. Hylan A and B are derivatives of sodium hyaluronate extracted from rooster combs. Hylans are also found in large amounts in synovial fluid, which make them perfect viscosupplements.

What is in the box?

Each box of these orthopedic injections comes with the stated preloaded glass syringe or syringes, patient record labels to ensure traceability, and a product information leaflet. Needles are not included and must be obtained separately. It is recommended to use sterile 18G to 22G needles, depending on the size of the affected joints.

What is the duration of effect for these products?

Synvisc is administered weekly for a total of three injections. For both products, patients will start noticing improvements within a month after completing a full course of treatment. These desirable effects can last for approximately 6 months, after which the administered gel will disintegrate into the surrounding tissues. Patients can get more injections once the initial effects wear off. Please note that the residence time of these products varies on an individual basis, depending on patients’ ages, health conditions, and lifestyle choices.

What is the storage condition?

These knee injections must be stored away from light in a clean and dry room with a temperature ranging between 2℃ to 30℃. Do not freeze these knee injectables.

What is the shelf life?

These orthopedic injectables have a shelf life of 36 months from the date of manufacture. Do not use the product past the expiration date listed on the package.