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Manufacturer: Croma
Active Substance(s) : Hyaluronic acid
Strength: 23mg/ml
Pack Size: 1-1ml prefilled syringe
Accessories: Package insert, 2-27G 1/2
Other Known Names: PRINCESS® VOLUME
You can save $18.00 if you add an additional 5 units to your cart.

Saypha Volume is a hyaluronic acid (HA) dermal filler that comes as a viscoelastic gel solution and is indicated for treating deep wrinkles and folds, restoring volume loss, and defining facial contours. HA is naturally found in the body and is important insomuch that it keeps the skin hydrated and maintains the elasticity and suppleness of the skin’s surface. Administering this treatment brings back the youthful and revitalized look of one’s skin; it can even create definition and volume to hollow areas of the face.

What Saypha Volume is formulated to do?

Chroma Pharma, the maker of Saypha Volume, is one of the leading pharmaceutical companies in Europe and specializes in orthopedics, ophthalmology, and viscoelastics. Their range of fillers incorporate proprietary Supreme Monophasic and Reticulated Technology (SMART). This technology, in turn, paves the way for a highly dense three-dimensional matrix that allows this product to resist fast absorption of its HA molecules and, as a result, remain effective in the skin for a longer period time.

When injected into the deep dermis or subcutis, this filler effectively improves facial creases and wrinkles, such as nasolabial folds, perioral wrinkles, forehead furrows, and marionette lines. In addition to smoothing out lines, wrinkles, and folds, it promotes the hydration and volumization of the treated area(s). This variant is ideal for those who need volume enhancement and those with severe wrinkles and depressions.


This product is manufactured by Croma-Pharma GmbH.


This product originates from Vienna, Austria.

Side effects

As with any dermal implant injection, post-inflammatory reactions are common. However, these are often mild and usually only last from a few days up to a week. The following is a non-exhaustive list of adverse effects related to Saypha Volume injection:

  • Inflammatory reaction: redness, swelling, and pain
  • Bruising
  • Itching
  • Tenderness
  • Formation of tiny bumps under the skin

This is not a complete list of side effects. Refer to the package insert for a full list of side effects, warnings, and contraindications. If any adverse effects are prolonged or worsen, your patient should contact you or another medical professional.

Which skin type is it good for?

Saypha Volume works on all skin types, but it provides significant results on dry, dull, and dehydrated skin with various signs of aging or photo damage. As the name suggests, it works well on mature skin that lacks volume. Those who require contouring or the redefining of their facial features, such as the cheekbones and the chin, will also benefit from this filler.

Precautions and contraindications

It is rare for an allergic reaction to occur following an injection of this product. Skin testing is not required because the main ingredient of this filler is fully biocompatible. However, care should be taken when administering the product on patients with compromised immune system and other concurrent medical conditions. This should not be used on patients who are under 18 as well as on pregnant and/or breastfeeding women.

Packaging information

Each package of Saypha volume contains disposable glass syringes that are prefilled with this solution, needles, a set of removable labels in the packaging for easy tracking, and a package insert that contains information use instructions, precautions, contraindications, and side effects. Verify the integrity of the gel solution and needles before use.

Suggested Usage

  • Saypha Volume is to be injected into the deep dermis or subcutis.
  • Ask the patient to wash the treated area with soap and water and to make sure that no traces of makeup, oil, and dirt are left.
  • Disinfect the area in accordance with proper aseptic techniques and standards.
  • Using the 27G ½” needle provided, slowly inject the contents of the syringe. The injection technique and amount of product needed depends on the area to be treated and patient’s desired result.
  • Gently massage the treated area to distribute the product evenly.


This Saypha variant contains 23 mg/ml of cross-linked hyaluronic acid in a phosphate buffered saline (pH 6.8-7.6 q.s.). The main ingredient is obtained from Streptococcus equi bacteria. Each syringe contains 1ml of this solution and have been sterilized using steam.

Frequently Asked Questions

What is in the box?

  • One sterile, prefilled syringe that contains 1ml of this solution
  • Two 27g ½” disposable sterile needles
  • Set of traceability labels
  • Package insert

How long did the effects last?

Saypha Volume has a longer duration of effect compared to other fillers in the SMART line. Its beneficial effects last for about eight to 12 months. The degree of corrections and longevity of the treatment may vary from patient to patient.

How should the product be stored?

Store the product away from direct sunlight at a temperature between 2℃ and 25℃. Do not freeze this product.

How long does the product last?

  • It is safe to use this product up to two years from its manufacturing date.
  • Verify the expiration date on the packaging and the integrity of the syringe before use. Do not use Saypha Volume if it has expired.