Prevelle Silk vs Juvederm: Which Filler is Better?

Prevelle Silk is one of the latest hyaluronic acid fillers on the market. It is co-developed by Genzyme Corporation and Mentor Corporation (a manufacturer of breast implants which operates as a subsidiary of Johnson and Johnson). In contrast, Juvederm has a longer history of use and is one of the most popular aesthetic filler brands. Juvederm is manufactured by Allergan, an Irish pharmaceutical company that operate worldwide.

Prevelle Silk is indicated for the temporary treatment of moderate to severe aging-related folds and wrinkles. The filler is particularly useful in treating wrinkles and lines with minor irritation, including nasolabial folds. Nasolabial folds are furrows extending from the angle of the mouth to the base of the nose. In addition, Prevelle Silk is effective for correcting creases between the eyebrows, horizontal lines on the forehead, perioral lines, marionette lines, smile lines and crow’s feet (lateral canthal lines). Having volumizing properties, Prevelle Silk can also be used to contour and define the lips.

The indications of Juvederm fillers are very similar to that of Prevelle Silk. Juvederm fillers such as Voluma can be used for augmenting the cheeks in adult patients who suffer from mid-face volume deficit caused by aging. Similar to Prevelle Silk, Juvederm injectables (particularly Juvederm Vollure, Juvederm Ultra and Juvederm Ultra Plus) are indicated for the treatment of moderate to severe wrinkles and folds on the face. Plus, Juvederm fillers (e.g. Juvederm Ultra) can be injected into the perioral area or the lips for augmentation.

Prevelle Silk vs Juvederm: What are the ingredients?

Both Juvederm and Prevelle Silk are formulated with hyaluronic acid of non-animal origin.

Found abundantly in the cartilage and skin, hyaluronic acid is a naturally occurring substance that has water retention properties. The compound plays an important role in the maintenance of skin hydration. Unfortunately, the levels of hyaluronic acid decline with advancing ages, causing the signs of aging to emerge. Dermal fillers such as Juvederm and Prevelle Silk are able replenish the lost hyaluronic acid in the body. Through their smoothing and volumizing actions, they reduce the appearance of wrinkles and lines while adding volume to sunken facial areas, helping patients to look younger.

Both Prevelle Silk and Juvederm (particularly the Ultra range) are formulated with lidocaine, a compound that has anesthetic properties. Through the inhibition of voltage-gated sodium channels (and hence, ionic fluxes), lidocaine induces regional anesthesia to alleviate pain and discomfort related to injection. Thanks to the lidocaine in the formulations, the treatment process is virtually painless.

Are they really different?

Containing similar active ingredients, Juvederm and Prevelle Silk are used for the same indications and have comparable effectiveness. Perhaps the biggest difference between Prevelle Silk vs Juvederm is the price and duration of action.

While Prevelle Silk is not as long lasting as most Juvederm, its price is relatively lower. This makes Prevelle Silk perfect for patient who cannot afford a pricier filler but still want instant results. Prevelle Silk can last for up to two to three months.

Depending on who you ask, the shorter length of action can be a good or bad thing. Prevelle Silk is ideal for first-time patients who are concerned about how their look will be after filler injections. If they find the results satisfactory, they can come back for a longer-lasting filler. In contrast, Prevelle Silk may not be suitable patients who are looking for a more durable results, or those who prefer fewer repeat injections.

Manufactured using proprietary cross-linking technologies, most Juvederm injectables have a prolonged duration of action. Juvederm fillers can last up to 18 months or more depending on the filler used.

As with other dermal fillers, the duration action is influenced by a number of factors, including the structure and type of the skin, age and lifestyle (all of which vary greatly among patients). Other factors include the location of treatment area and injection technique. Apart from that, the rate at which metabolism occurs can also greatly affect the durability of Prevelle Silk and Juvederm.

Prevelle Silk vs Juvederm: Which is safer?

Unsurprisingly, these fillers share similar safety profiles. As with many other fillers, they may cause minor injection site reactions such as mild swelling and redness. Having said that, these reactions are mostly self-limiting, resolving themselves in a few days without the need for further treatment. Derived from a non-animal source, Juvederm and Prevelle Silk are associated with a minimal risk of immunogenic reactions.

Having been approved by various health authorities, Prevelle Silk and Juvederm are generally well tolerated. Both Juvederm and Prevelle Silk have obtained approval from regulatory agencies, which means their safety and clinical efficacy have been reviewed and validated. They are not likely to cause any significant complications as long as they are injected correctly (and carefully). When it comes to filler treatments, the main thing to consider is the doctor’s expertise. The lack of experience or anatomical knowledge can potentially jeopardize the safety of patients.

In addition, poor injection technique may also lead to catastrophic consequences. For instance, accidental injection into an artery can cause severe, irreversible consequences such as stroke, skin necrosis, blindness, cerebral hemorrhage and temporary or permanent vision impairment. Therefore, patients should look for board-certified practitioners who have experience using dermal fillers.

Prevelle Silk vs Juvederm: Which one is right for me?

Both Prevelle Silk and Juvederm are designed to deliver visible yet natural looking results. Plus, the injection process is minimally invasive and has virtually no downtime. Having pretty much the same indications, the biggest difference between Prevelle Silk and Juvederm is their duration of action. The durability of Prevelle Silk is substantially shorter than that of Juvederm. However, this is not necessarily a bad thing. It allows first-time patients to try filler injections without the commitment. Apart from that, Prevelle Silk serves as a more affordable alternative to patients who cannot afford the pricier Juvederm.

In order to select the most appropriate filler, doctors will need to carefully assess the needs of patients while considering their budget. Ultimately, it all comes down to patient preference.