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Is Mesotherapy safe?

Mesotherapy is a cosmetic technique that involves injecting a solution, which varies based on the treatment type, into the mesoderm, a layer of tissue and fat underneath the skin. Mesotherapy treatment involves multiple injections of usually vitamins and minerals into areas of the body that require improvement in some way or another. Mesotherapy treatment was first developed in 1958 and has since been used for a number of cosmetic medical procedures. It has been a very popular cosmetic procedure in Europe and South America for decades, and has becoming increasingly popular in the United States in recent years. There are some side effects associated with mesotherapy treatment, though they are all mild and temporary. These side effects include skin irritation such as pain and burning at the injection site, as well as bruising and swelling. Injections could also cause temporary numbness or skin discoloration, and some patients report feeling nauseous after treatment.

What is used in mesotherapy?

Mesotherapy involves using very fine needles to administer very small doses of a solution with each injection. These solutions are usually a mixture of vitamins, minerals, amino acids, or other homeopathic solutions. These mixtures are often called a “mesotherapy cocktail” and will trigger a biological response that helps to hydrate the skin, improve skin tone, and sometimes reduce lines and wrinkles:

  • Vitamins, such as vitamins C, B5, B8, B6, E, A, and B12;
  • Minerals, such as potassium chloride, magnesium sulphate, and calcium chloride;
  • Amino acids, such as lysine;
  • Nucleic acids;
  • Hyaluronic acid;
  • And coenzymes.

What you should know about mesotherapy injections

There are a few things you should know about mesotherapy injections before deciding on treatment. This includes:

  • What injections are made up of – Aside from the medications previously mentioned, there are also a number of other ingredients that may be found in a mesotherapy cocktail, depending on the desired effects of the mesotherapy treatment. Some of these common ingredients include:

    • Phosphatidylcholine
    • L-Carnitine
    • Retinoic Acid
    • Minoxidil
    • Dutasteride
    • Multi-vitamins
    • Biotin
    • Aminophylline
    • Glycolic Acid
    • Yohimbine
    • D-Panthenol
    • Glycolic Acid
    • DMAE
    • Collagenase
    • Caffeine
    • Melilotus
    • Procaine
    • Lidocaine
    • Marcaine
    • Pentoxifylline
    • Artichoke Extract
    • Taurine

  • The cost of mesotherapy – The cost of mesotherapy treatment depends both on the issue you are trying to resolve with treatment, and the amount of sessions required to produce the desired effects. However, on average, a single mesotherapy treatment session can cost anywhere between $250 and $600. Additionally, as mesotherapy is a cosmetic procedure, most insurance companies will not cover the cost of treatment.
  • Side effects – While mesotherapy treatment is a safe medical cosmetic procedure that has been performed for decades, there are some side effects associated with mesotherapy injections. Most reactions are temporary and will resolve themselves without intervention within a week or two, if that. These reactions include burning, itching, or soreness around the injection site, Bruising or swelling may also occur. More rarely, nausea or a hypersensitive reaction may occur. Very rarely, hematoma, skin necrosis, abscess, hyperpigmentation, or infection may occur.


Mesotherapy can be used to administer treatment for a number of cosmetic issues. These include:

  • Facial Rejuvenation – This is one of the most popular mesotherapy treatments, and helps patients look younger and more rejuvenated. These treatments offer a marked improvement in the skin of the face to smooth out light wrinkles and lines and improve overall appearance of the face. Treatment is usually administered over 4 sessions taking place at 2 to 3 week intervals.
  • Fat reduction (weight loss) – Mesotherapy treatments for fat reduction has become a popular alternative to riskier liposuction treatments. However, this treatment only works for localized fat deposits and works best as a body contouring solution as opposed to a weight loss solution. Treatment will be most effective on individuals who maintain a healthy diet and exercise routine, but have certain problem areas that are resistant to weight loss techniques. These injections usually require 2 to 4 treatments taking place at 2 to 4 week intervals, though this will depend on the area being treated. This can be performed on the stomach, love handles, thighs, buttocks, abdomen, neck, arms, legs, and chin.
  • Cellulite treatment – This mesotherapy treatment helps patients deal with cellulite, a cosmetic issue that is not easily treated. It works best on cases of mild cellulite, and requires on average 3 to 4 treatments, taking place at 3 to 4 week intervals.
  • Lower Blepharoplasty – This mesotherapy treatment helps reduce the appearance of bags and puffiness under the eyes by removing excess fat and firming the skin. Recovery time may be a bit longer for this treatment, with swelling lasting up to 6 weeks in some cases. It is recommended that patients take cortisone before injections. This procedure may only require 1 treatment session, though at times a second sessions may be needed, and should take place 6 weeks after the initial session.

Thing to expect before and after mesotherapy

Prior to your mesotherapy treatment, expect to have an initial consultation with the medical practitioner administering the treatment. This consultation will involve a discussion of your medical history and your goals and desired results from the procedure. Additionally, doctors may perform an allergy test, to ensure there will be no negative reaction during or after treatment. The procedure itself will be very quick, likely taking around 30 minutes, though some sessions may last up to an hour, depending on the area and issue being treated. As the needles used for injection are so tiny, little to no pain will be experienced, though there may be some slight pain or discomfort as a side effect after the procedure is complete.  After mesotherapy treatment, there may be some mild side effects experienced, but there is no downtime required, meaning patients may return to most if not all of their daily activities.


Mesotherapy is a non-surgical, minimally invasive, safe, and effective treatment that provides correction and improvement in a number of areas in the body. Mesotherapy treatments can help patients feel more comfortable and confident in their bodies, and are a great alternative to more serious surgical cosmetic procedures such as liposuction or facelifts. As with all medical procedures, it is important to find a licensed and experienced professional to administer mesotherapy treatments for the safest and best results.

Disclaimer: These articles, and any views and opinions expressed, are not endorsed by Raskel Medical. The articles are strictly for informational purposes and should not be considered medical advice. Raskel Medical does not check or edit the content of these articles for medical accuracy. Contact your medical practitioner for any medical advice needed.