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Azzalure is a local muscle relaxant composed of botulinum toxin type A. This medicine is manufactured by French pharmaceutical company Ipsen, and marketed worldwide by Galderma. There is 125 Speywood units of botulinum toxin A in each vial.
The sterilized white powder must be reconstituted with 9mg/ml (0.9 %) sodium chloride solution. Only certified physicians who are experienced in handling neurotoxins should conduct medical procedures using this injectable.
This medicine was initially marketed in various countries as the brand name Dysport®. Despite its infamous toxicity, this neurotoxin is famed worldwide due to its excellent safety profile and medical and aesthetic performance.
The active composition—Clostridium botulinum toxin A haemagglutinin complex—has been used for over 20 years. In 2009, Dysport received approval from Medicines and Healthcare Products Regulatory Agency (MHRA) for the treatment of moderate to severe glabellar lines (vertical "frown" lines between the eyebrows) in patients below 65 years old under the brand name Azzalure.
For skeletal muscles to contract and produce movements ordinarily, conscious efforts are required to generate necessary nerve and chemical impulses. Only then can movement, such as facial expressions, occur as intended. Unfortunately, problems arise when too muscle contractions occur constantly, often leading to painful spasms. On the other hand, some patients may also notice that their wrinkles are severely pronounced during habitual facial expressions.
Azzalure works to alleviate these issues, particularly aesthetic problems. This muscle relaxant contains 125 Speywood units of Clostridium botulinum toxin A haemagglutinin complex, which temporarily relaxes injected muscles. The toxin acts at the nerve-muscle junction to prevent impulses from being released, thus, preventing muscle contractions. Wrinkles are also not apparent during facial expressions.
Azzalure contains highly purified units of Clostridium botulinum toxin A haemagglutinin complex. Once injected, the toxin works locally by only relaxing injected muscles.
The Speywood units of Azzalure cannot be used interchangeably with other botulinum toxin preparations due to the type of units. As well, unlike other toxins, this brand is specifically indicated for the treatment of facial wrinkles.
This neuromodulator is specially designed and approved for improving skin affected by moderate to deep-set glabellar lines (frown wrinkles) and lateral canthal lines (crow’s feet). Is is suitable for most skin types, but should not be used for patients under the age of 18 or patients over the age of 65. As well, this toxin should not be injected into areas with signs of infection.
Following the procedure, your patients may develop some common side effects. Be sure to take precautions when injecting this neuromodulator, as it should not be injected into a blood vessel.
The most common adverse reactions included headache and inflammatory responses to the injection. These effects generally resolve within a week.
Educate your patients to quickly identify uncommon side effects. Refer to package insert for more list of possible side effects.
Azzalure is an efficient local muscle relaxant that is approved for treatment of aesthetic imperfections, such as vertical frown lines and crow’s feet. The neurotoxin has also undergone extensive purification process for better patient safety profile.
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