Radiesse vs Voluma

Radiesse and Juvederm Voluma are dermal fillers with anti-aging properties. Radiesse contains calcium hydroxyapatite or CaHA microspheres suspended in an aqueous gel as its active ingredient while Juvederm Voluma is a hyaluronic acid-based preparation.

Conventionally used for treating moderate to severe facial wrinkles and folds, Radiesse is often used off-label for treating marionette lines and augmenting cheeks. Juvederm Voluma is specially designed for cheek augmentation and was the first filler approved by the Food and Drug Administration (FDA) for the correction of volume deficit in the mid face due to aging.

Off-Label vs. Approved Use

FDA approval indicates that a product has been officially approved for a particular indication. In order to obtain FDA approval, findings from the manufacturer’s testing need to be reviewed and validated. Off-label use refers to the use of a product for an indication that has not been approved by FDA. While not advertised as an indicated use, off-label uses are generally considered safe, such as in the case of Radiesse.

Radiesse and Juvederm: How are They Different?


Radiesse contains synthetic calcium hydroxylapatite microspheres that are suspended in an aqueous gel carrier. Having a unique mode of action, the microspheres stimulate collagen synthesis in the skin, replenishing lost collagen. This delivers natural yet dramatic volumizing results. The biodegradable microspheres are metabolized naturally without being absorbed by the body. The CaHA microspheres in Radiesse are designed to be biocompatible, which minimizes risk of an allergic reaction. In contrast, Juvederm Voluma contains hyaluronic acid as its main ingredient. Hyaluronic acid is a naturally-occurring component found abundantly in the skin. Having water retention properties, hyaluronic acid swells up when in contact with water. Not surprisingly, Juvederm Voluma draws in a greater amount of water than Radiesse. Hyaluronic acid is biodegradable and gradually degrades– the results of these fillers are temporary. Unlike calcium hydroxylapatite, hyaluronic acid is eventually resorbed by the body.

Lifting Effects

Compared to injections for correcting nasolabial folds, injections for cheek augmentation are much deeper.

Specially formulated for cheek augmentation, Juvederm Voluma delivers lifting effects that last. Its superior lifting abilities can be attributed its high elastic modulus. Elastic modulus refers to the ability of a filler to recover and revert to its original shape after movements such as smiling.

Radiesse also delivers superior lifting effects. Once administered, the CaHA microspheres function as a scaffold upon which collagen regenerates. Notably, the weight of Radiesse is the highest amongst all injectable fillers. Although not officially indicated for cheek augmentation, Radiesse has been used for this purpose by practitioners around the world without causing severe complications. The results have been remarkable.

So, how does Radiesse’s off-label use for cheek augmentation fare against Juvederm Voluma’s approved use? The general consensus is that the lifting abilities of Radiesse are comparable to that of Juvederm.

Both dermal fillers have excellent lifting properties and are ideal for cheek augmentation.

Duration of Action

As claimed by its manufacturer Allergan, Juvederm Voluma can last for up to two years. Radiesse, on the other hand, is estimated to last for nine to 18 months. At first glance, it appears that Juvederm Voluma is longer lasting than Radiesse. However, the term “up to” denotes anything from one to two years. It does not necessarily mean that the filler will last for two complete years.

Therefore, Radiesse may be longer lasting than Juvederm Voluma in some patients, with an average length of action of 18 months. The actual duration of action differs greatly among patients and is influenced by a number of factors, such as the patient’s rate of metabolism and the amount of filler used.


One syringe of Juvederm Voluma (containing 2ml of injectable gel) can cost between $750 and $1,000, while the price range of Radiesse is $600 to $800. Juvederm may have a higher price, but each syringe contains more product in comparison to Radiesse.

Many factors can affect the price of a filler, including the location of the clinic.

Total treatment cost is often determined by the amount of filler needed, which means that aesthetic injections are not always affordable. It is sometimes impossible to achieve the desired results with a limited budget. While it is understandable that patients desire an affordable price, cost should not be the only consideration when it comes to dermal fillers.


Having superior lifting abilities, both Radiesse and Juvederm Voluma have demonstrated excellent results in cheek augmentation. While similar in many aspects, they differ in terms of ingredients, price, and duration of action.

Approved for this use by the FDA, Juvederm Voluma is clinically proven to be safe and effective. Radiesse, while being used off-label, has the added benefit of boosting - collagen regeneration and delivering natural results.