Juvederm vs Radiesse for Marionette Lines: Effectiveness Compared

Juvederm Ultra and Juvederm Ultra Plus are predominantly used in the treatment of wrinkle correction, such as nasolabial folds and, of course, marionette lines. Juvederm Ultra is primarily indicated for the treatment of mild and moderate lines, while Ultra Plus is used for deeper marionette lines. Juvederm Vollure is also used to correct superficial marionette lines. This particular filler is much thinner in viscosity compared to Ultra and Ultra Plus; therefore, it is best for superficial lines. The thinness of the gel also lowers the possibility of over-plumping, ensuring natural results.

Radiesse, on the other hand, does not offer a variety of fillers. It comes in one formulation with or without lidocaine. The Radiesse dermal filler is, nevertheless, used to treat marionette lines effectively. This dermal filler has been proven great regarding the restoration of  elasticity and collagen in this area of the face, which makes it minimally invasive and long-lasting. It is, however, essential to keep in mind that the product is usually intended to address deep folds and wrinkles as well as cheek augmentation.


Juvederm is a hyaluronic acid-based dermal filler which makes it a perfect product choice for marionette lines treatment. Some doctors prefer dermal fillers containing hyaluronic acid as they can be easier to work with and are reversible. Hyaluronic acid also provides necessary hydration and structure to the skin.
Radiesse is made of calcium hydroxylapatite. While some doctors may prefer the reversibility of hyaluronic acid-based fillers, many turn to Radiesse to help stimulate natural collagen production.
In a study comparing Juvederm Ultra Plus to Radiesse, researchers found that Radiesse produced better results and required less gel.

Comparing the fillers

Radiesse is best for deep marionette lines. Juvederm, on the other hand, can treat superficial to deep lines, depending on the filler used.
Other studies found that Radiesse can cause more lumps under the skin in comparison to hyaluronic acid-based fillers. As well, Radiesse is also associated with greater inflammation.
Lastly, the longevity of the results also differs. The results of Radiesse can last for up to 18 months, while Juvederm Ultra Plus can last up to a year.
In order to determine which filler is best for you, you should consult a licensed practitioner regarding the severity of your marionette lines. You should also discuss your doctor's experience with each filler. Many doctors find that the skill of the injector can reduce the chances of adverse effects with Radiesse, such as an “overstuffed“ look.


Both Juvederm and Radiesse are known to correct marionette lines quite effectively. One of the biggest differences between these fillers is that Radiesse is a stimulatory filler and Juvederm is a wrinkle filler. Radiesse is generally used to correct volume loss, as it stimulates to production of collagen. This makes it a great option for those who may need additional volume in the lower cheek area. Juvederm, on the other hand, is often suggested as an introductory filler for those who have never received treatment before. While both are effective, it is important to use the filler that best suits your needs.