Juvederm vs Radiesse for Marionette Lines: Effectiveness Compared

Juvederm Ultra and Juvederm Ultra Plus are predominantly used for the treatment of wrinkles, including nasolabial folds and marionette lines. While the former is primarily indicated for the treatment of mild and moderate lines, the latter is indicated for deeper folds. Juvederm Vollure, which is a thicker formula, is used to correct superficial marionette lines.

Radiesse, on the other hand, does not offer a variety of fillers. It comes in one formulation, with or without lidocaine. Designed to treat deep folds and wrinkles, as well as augment cheeks, this long-lasting filler effectively treats marionette lines, restoring elasticity and collagen.


Juvederm is a hyaluronic acid-based dermal filler, which makes it the perfect choice for treating marionette lines. Some doctors prefer dermal fillers containing hyaluronic acid as they are easier to work with and reversible. Hyaluronic acid also provides necessary hydration and structure to the skin.
Radiesse contains calcium hydroxylapatite, which stimulates natural collagen production. In a study comparing Juvederm Ultra Plus to Radiesse, researchers found that Radiesse produced better results and required less gel.


When comparing the two fillers, Radiesse is best for deep marionette lines. Juvederm, on the other hand, can treat superficial to deep lines, depending on the formulation used. Studies have found that Radiesse can cause more lumps under the skin in comparison to hyaluronic acid-based fillers. It is also associated with greater inflammation.

The longevity of the results of these fillers also differs. The results of Radiesse can last for up to 18 months, while the results of Juvederm Ultra Plus can last for up to one year. One of the biggest differences between these fillers is that Radiesse is a stimulatory filler and Juvederm is a wrinkle filler.

In order to determine which filler is best for you, consult a licensed practitioner regarding the severity of your marionette lines. Be sure to discuss your injector’s experience with each filler as their skill reduces the chances of adverse effects.