Crespine Gel Composition

Crespine Gel is an orthopedic injectable prescribed for the treatment of knee pain caused by osteoarthritis. Administered via intraarticular injection, it helps to cushion and lubricate the joint, relieving knee pain.

Crespine Gel is supplied in a sterile prefilled syringe and comes with four traceability labels and a product insert. Traceability labels can be used to keep track of what was injected. Crespine Gel is a product of BioPolymer, a medical technology company based in Germany.

Composition and Ingredients

Crespine is formulated with 14mg/ml of cross-linked hyaluronic acid and 1mg/ml non-crosslinked hyaluronic acid as its active ingredients. While Crespine does not contain a local anesthetic, the Plus formulation contains an additional 3mg/ml of prilocaine.

Made of naturally occurring ingredients, Crespine Gel does not contain any medications, making it perfect for osteoarthritis patients who prefer a drug-free alternative. It is especially useful for patients who are unresponsive to conventional treatments such as physical therapy and oral analgesics.

The hyaluronic acid in this injection is sodium hyaluronate. Derived from a non-animal source, there is a lower risk of immunogenic reaction than with some other orthopedic injections.

Knee pain in osteoarthrosis is typically caused by the loss of synovial fluid. Hyaluronic acid effectively reduces the sensation of pain by supplementing the degraded synovial fluid. Having similar viscoelasticity and consistency, Crespine mimics the actions of the natural synovial fluid, thereby improving joint efficiency.

Hyaluronic acid acts on the surface of the cartilage to form a protective layer. This cushions and lubricates the joint while absorbing shock and eliminating friction. As a result, knee stiffness is reduced. In the long term, Crespine Gel prevents the progression of osteoarthritis, eliminating the need for joint replacement surgeries.

Crespine Gel is formulated with potent ingredients that have been tested for safety. Patients are unlikely to experience any major side effects apart from mild swelling, joint stiffness, and transient redness, all of which are self-limiting in nature.

Thanks to its cross-linked hyaluronic acid, Crespine Gel delivers pain-relieving results that last. In most cases, results last for approximately 6 to 8 months, although individual results may vary. For best results, patients are advised to repeat treatment every 8 months. To maintain the potency of the ingredients, it is recommended to keep Crespine Gel orthopedic injections at a temperature of between 2 and 25°C.

Patients who are pain-sensitive may consider Crespine Gel Plus, a similar formulation infused with prilocaine. Prilocaine helps decrease injected-related discomfort and pain, making the treatment process more comfortable.

Dosage and Administration

Each syringe is prefilled with 2ml of injectable gel. Treatment requires one 2ml injection, which usually takes 10 to 20 minutes to complete. It takes 5 to 7 days to see the results of Crespine Gel. Therefore, patient are not likely to feel benefits immediately after treatment.

To ensure patient safety, Crespine Gel should only be administered by a certified medical professional. Before injection, the treatment area should be sterilized thoroughly. Crespine should be injected intraarticularly into the synovial cavity of the joint. After injection, the used needle and syringe should be safely disposed of.

About Osteoarthritis

Osteoarthritis is a degenerative, inflammatory disease that affects the joints. It is commonly characterized by abnormal growths which are medically known as bone spurs or osteophytes. Being progressive in nature, osteoarthritis is most likely to affect middle-aged patients. It occurs when the articular cartilage starts to break down, exposing the bones. Over time, the friction between the bones leads to significant joint damage, resulting in symptoms such as stiffness, swelling, and pain.

In addition to these symptoms, patients often experience reduced joint movement. The symptoms may come and go in the early stages of osteoarthrosis and worsen over time. Conventionally, oral pain medications and physical therapy are used as treatment. Crespine Gel serves as an alternative for patients who respond inadequately to these treatment modalities.